姓名：张琳
职称：讲师
研究方向：食用植物提取物对老年痴呆的预防和辅助治疗作用机制研究；多肽水凝胶的研究
办公电话：13875860686
电子邮箱：zhanglin840514@126.com
学历背景
2013年毕业于中南大学获博士学位，2009至2011年在加州州立大学洛杉矶分校生物与化学系做访问学者。现任中南林业科技大学食品科学与工程学院讲师。
学术简介
主要从事食用植物提取物对老年痴呆的预防和辅助治疗作用机制研究；多肽水凝胶对食品营养成分的控制释放作用研究，研究内容涵盖对老年痴呆具有潜在的治疗和预防效果的食用植物提取物的筛选方法的建立，活性成分的分离鉴定，活性成分的作用机制，活性成分在生物体内控制释放等方面。近年来在ACS Chemical Neuroscience、Biochemistry、Electroanalysis、Analytical Biochemistry、Analytical Chemistry等国际期刊上发表SCI论文13篇（其中通讯作者和第一作者6篇），论文被引用30余次。作为主持人承担国家自然科学基金青年项目、湖南省自然科学基金青年项目、湖南省教育厅科学研究项目、长沙市科技计划项目重点项目等多项科研课题。
学术成就
代表性论文 (IF=2014 5-year impact factor；* 通讯作者)
Tao Yang, Fang Zhu, Tianxiao Zhou, Jianzhong Cao, Meiyi Zhang, Yibo Xie, Yan Wang, Dong-ShengCao, Qinlu Lin, Lin Zhang*, Label-Free, Water-Soulbe Fluorescent Peptide Probe for Sensitive and Selective Determination of Copper Ions, Analytical sciences, accepted., 2016（IF = 1.3）
Lin Zhang, Yuanqiang Hao, Xiaoying Wang, Yunfei Long, Angela Ramos, Dianlu Jiang, Xiaohua Ma, Qinlu Lin and Feimeng Zhou*, Optically transparent electrodes modified with sulfide ion-covered CdS quantum dots for sensitive photoelectrochemical detection of sulfhydryl-containing compounds, Electroanalysis, 27，（8）：1899-1905, 2015（IF = 2.9）
Lin Zhang, Gargey Yagnik, Yong Peng,Jianxiu Wang, H. Howard Xu, Yuanqiang Hao, You-Nian Liu, and Feimeng Zhou*,Kinetic studies of inhibition of the amyloid beta (1–42) aggregation using a ferrocene-tagged β-sheet breaker peptide, Analytical Biochemistry, 434 (2): 292-299, 2013（IF = 3.0）
Lin Zhang, Tianhan Kai, Zhifang Sun, Yuanqiang Hao, Qiuyun Tu, and Feimeng Zhou*,A ferrocene-tagged amyloid-β fragment for rapid screening of aggregation inhibitors from natural compounds by HPLC-electrochemical detection, Electroanalysis, 25 (7): 1659-1664, 2013（IF = 2.9）
Lin Zhang, Gargey Yagnik, Dianlu Jiang, Shuyun Shi, Peter Chang, and Feimeng Zhou*, Separation of intermediates of iron-catalyzed dopamine oxidation reactions using reversed-phase ion-pairing chromatography coupled in tandem with UV–visible and ESI-MS detections, Journal of Chromatography B, 911, 55-58, 2012（IF = 2.8）
Dianlu Jiang, Lin Zhang（并列第一作者）, Gian Paola G. Grant, Christopher G. Dudzik, Shu Chen, Sveti Patel, Yuanqiang Hao, Glenn L. Millhauser, and Feimeng Zhou*, The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques, Biochemistry, 52 (3): 547-556, 2013（IF = 3.2）
Tianhan Kai, Lin Zhang，Xiaoying Wang, Aihua Jing, Bingqing Zhao, Xiang Yu, Jie Zheng, Feimeng Zhou, Tabersonine inhibits amyloid fibril formation and cytotoxicity of Aβ (1–42), ACS Chemical Neuroscience, 6, 6, 879-884, 2015 (IF = 3.9）
Shu Chen, Lin Zhang, Yunfei Long, and Feimeng Zhou*, Electroanalytical sensors and methods for assays and studies of neurological biomarkers, Electroanalysis, 26(6): 1236–1248, 2014.(IF = 2.9）
Dianlu Jiang, Shuyun Shi, Lin Zhang, Lin Liu, Bingrong Ding, Bingqing Zhao, Gargey Yagnik, and Feimeng Zhou*, Inhibition of the Fe(III)-catalyzed dopamine oxidation by ATP and its relevance to oxidative stress in Parkinson’s Disease, ACS Chemical Neuroscience, 4 (9): 1305-1313, 2013 (IF = 3.9）
Chuan-Wan Wei, Yong Peng, Lin Zhang, Qiyu Huang, Ming Cheng, You-Nian Liu*, Juan Li, Synthesis and evaluation of ferrocenoyl pentapeptide (Fc-KLVFF)as an inhibitor of Alzheimer’s Ab(1–42) fibril formation in vitro, Bioorganic & medicinal chemistry letters, 21 (19): 5818-5821, 2011 (IF = 2.5）
Chengshan Wang, Lin Liu, Lin Zhang, Yong Peng, and Feimeng Zhou*, Redox reactions of the a-synuclein-Cu2+ complex and their effects on neuronal cell viability, Biochemistry, 49 (37): 8134–8142, 2010 (IF = 3.0）
Yong Peng, Dianlu Jiang, Lei Su, Lin Zhang, Ming Yan, Juanjuan Du, Yufeng Lu, You-Nian Liu, and Feimeng Zhou*. Mixed monolayers of ferrocenylalkanethiol and encapsulated horse radish peroxidase for sensitive and durable electrochemical detection of hydrogen peroxide. Analytical Chemistry, 81 (24): 9985–9992, 2009(IF = 5.9）
Ling-Bin Ou, You-Nian Liu*, Jianxiu Wang, Lin Zhang, Enhanced voltammetric detection of epinephrine at a carbon nanotube/nafion composite electrode in the presence of ascorbic acid, Journal of Nanoscience and Nanotechnology, 9 (11): 6614-6619,2009(IF = 1.4）
张琳，林亲录*，阳明辉，β-淀粉样多肽自聚集抑制剂的电化学筛选方法研究，化学传感器，2013, 33 (4):23-28
周天啸，刘馥歌，杨涛，张琳*，自组装多肽水凝胶包埋大蒜精油的控释研究，粮食与油脂，2016,29（7）：14-18
实验室介绍
实验室现有硕士生3人。