食品质量与安全

一、基本情况

理学博士，副教授，硕士研究生导师，主要从事有机小分子荧光成像应用研究，包括环境暴露对食品安全与生命长周期健康评估、药物释放，药物分析、天然活性分子结构的修饰等，并取得了一系列原创性的研究成果。主持并结题国家自然科学基金1项，省部级3项，企业横向课题多项。迄今为止，已在国际权威期刊上以第一作者或通讯作者发表SCI 论文50余篇和2项授权专利，h指数26，这些研究成果得到了国际同行的高度评价和广泛关注。其中：1篇他引400余次，被标注为高被引论文（ESI前1%）；1篇热点论文（hot paper）；一区TOP论文：40余篇；影响因子大于10.0的10篇。

研究方向：环境暴露对食品安全与生命长周期健康评估、药物释放，药物分析、天然活性分子结构的修饰

招生学科/领域：食品安全、食品科学与工程、生物医药

联系方式：zhouly0817@163.com

二、工作与学习经历

2019.01~至今          中南林业科技大学食品科学与工程学院 副教授

2017.04~2018.12      中南林业科技大学食品科学与工程学院 讲师

2016.04~2016. 11      香港城市大学        助理研究员

2012.09~2015. 12      湖南大学            理学博士

三、主持的科研项目（课题）

1.国家自然基金（细胞器定位的气体信号分子双光子近红外荧光探针的设计合成及生物成像应用，主持，21605046），2017.01-2019.12

2.湖南省自然基金（细胞器靶向的双光子近红外荧光探针用于气体信号分子的研究，主持，2017JJ3060，2017.01-2019.12

3.湖南省面上用于老年痴呆诊断的双光子近红外比率荧光探针的构建及应用，主持，2023JJ30988，2023-2025.12

4.湖南大学化学生物传感与计量学国家重点实验室开放基金（细胞器靶向的双光子近红外荧光探针用于气体信号分子的研究，主持），2017-2019

5.长沙市科技局基金（细胞器靶向的双光子近红外荧光探针用于气体信号分子的研究，主持，kq1901140），2019-2020

6.2016年与企业合作，水溶性喜树碱的结构改造

7.2018年帮助企业开发水溶性有机硒化

四、主要奖励

2018年获得湖南省优秀博士学位论文；指导的研究生8人次获得国家奖学金，3人获得湖南省优秀硕士学位论文。

五、代表性成果

1、近5年代表性论文：

1. Ting Liu, Xiaomin Yuan, Kun Luo, Can Xie, Liyi Zhou^*. Molecular engineering of a new method for effective removal of cadmium from water. Water Research, 2024, 253, 121326. (通讯作者, IF>12, TOP, 1区，自然指数期刊).

2. Can Xie, Yongbo Peng, Zhen Zhang, Kun Luo, Qiaomei Yang, Libin Tan, and Liyi Zhou*. Tumor microenvironment activatable nanoprodrug system for in situ fluorescence imaging and therapy of liver cancer. Anal. Chem. 2024, 96, 5006-5013. (通讯，1区，TOP，自然指数期刊）

3. Xiaomin Yuan, Ting Liu, Kun Luo, Can Xie, Liyi Zhou^*. Neo-construction of a SO₂-tunable near-infrared ratiometric fluorescent probe for high-fidelity diagnosis and evaluation hazards of Cd²⁺-induced liver injury. Journal of Hazardous Materials, 2024, 466, 133653. (通讯作者, IF>13, TOP, 1区).

4. Kun Luo, Liyi Zhou^*, Can Xie, Qiaomei Yang, Libin Tan, Qinlu Lin. High-fidelity fluorescent probes for visualizing the inhibitory behavior of selenium on cadmium uptake in rice. Journal of Hazardous Materials, 2023, 457, 131748. (通讯作者, IF>13, TOP, 1区).

5. Longpeng Peng, Qiaomei Yang, LibinTan, LiyiZhou^*. Double-site-based a smart fluorescent sensor for logical detecting of sulphides and its imaging evaluation of living organisms. Journal of Hazardous Materials, 2022, 424, 127591. (通讯作者, IF=10.588, TOP, 环境1区).

6. Libin Tan , Qiaomei Yang, Longpeng Peng , Can Xie, Kun Luo, Liyi Zhou^*. Molecular engineering-based a dual-responsive fluorescent sensor for sulfur dioxide and nitric oxide detecting in acid rain and its imaging studies in biosystems. Journal of Hazardous Materials, 2022, 435, 1289471. (通讯作者, IF=10.588, TOP, 环境1区).

7. Weizhen Xu, Libin Tan, Jiaqi Zeng, Qiaomei Yang, Yizhuang Zhou, Liyi Zhou^*. Molecular engineering for construction of a novel ONOO⁻- activated multicolor fluorescent nanoprobe for early diagnosis and assessing treatment of arthritis in vivo. Biosensors and Bioelectronics, 2022, 209, 114242. (通讯作者, IF=10.641, TOP, 1区).

8. Qiaomei Yang, Yizhuang Zhou, Libin Tan, Can Xie, Kun Luo, Xiaowen Li, Miao Zeng, and Liyi Zhou^*. Rationally Constructed De Novo Fluorescent Nanosensor for Nitric Oxide Detection and Imaging in Living Cells and Inflammatory Mice Models. Anal. Chem. 2023, 95, 2452-2459. (通讯作者, IF>8, TOP, 1区，自然指数期刊).

9. Can Xie, Yizhuang Zhou, Kun Luo, Qiaomei Yang, Libin Tan, LiyiZhou^*. Activated Two-Photon Near-Infrared Ratiometric Fluorescent Nanoprobe for ONOO⁻Detection and Early Diagnosis and Assessment of Liver Injury. Anal. Chem. 2022, 94, 15518-15524. (通讯作者, IF>8, TOP, 1区，自然指数期刊).

10. Kun Luo, Mingyan Jia, Can Xie, Qiaomei Yang, Libin Tan, Xiaogang Liu, Liyi Zhou*. A unique NIR dye constructed mitochondrial anchoring fluorescent probe for highly selective selenocysteine detection and imaging in living cells and mice. Sensors & Actuators: B. Chemical, 2023, 375, 132944. (通讯作者, IF>9.2, TOP, 1区).

11. Libin Tan, Can Xie, Qiaomei Yang, Kun Luo, Liyi Zhou *. Rational construction of a robust nanoprobe for highly selective and sensitive nitrite and formaldehyde detection and imaging in real foods. Food Chemistry, 2023, 405, 134949. (通讯作者, IF>9.2, TOP, 1区).

12. Xiongjie Zhao, Gangqiang Yuan, Haiyuan Ding, Liyi Zhou^*, Qinlu Lin. A TP-FRET-based fluorescent sensor for ratiometric visualization of selenocysteine derivatives in living cells, tissues and zebrafish. Journal of Hazardous Materials, 2020, 381, 120918. (通讯作者, IF>9.32, TOP, 环境1区).

13. Libin Tan, Can Xie, Qiaomei Yang, Kun Luo, Liyi Zhou^*. Rational construction of a robust nanoprobe for highly selective and sensitive nitrite and formaldehyde detection and imaging in real foods. Food Chemistry, 2023, 405, 134949. (通讯作者, IF>9.2, TOP, 1区).

14. Kun Luo, Mingyan Jia, Can Xie, Qiaomei Yang, Libin Tan, Xiaogang Liu, Liyi Zhou^*. A unique NIR dye constructed mitochondrial anchoring fluorescent probe for highly selective selenocysteine detection and imaging in living cells and mice. Sensors & Actuators: B. Chemical, 2023, 375, 132944. (通讯作者, IF>9.2, TOP, 1区).

15. Weizhen Xu, Qiaomei Yang, Jiaqi Zeng, Libin Tan, Liyi Zhou^*, Longpeng Peng, Yizhuang Zhou, Can Xie, Kun Luo, Zhen Zhang.A biomarker (ONOO^-)-activated multicolor fluorescent probe for early detection and assessment of arthritis. Sensors & Actuators: B. Chemical, 2022, 359, 131565(通讯作者, IF>9.2, TOP, 1区).

16. Xiongjie Zhao, Chao Wang, Gangqiang Yuan, Haiyuan Ding, Liyi Zhou^*，Xiaogang Liu, Qinlu Lin. A dual-site modulated FRET-based two-photon ratiometric fluorescent probe for tracking lysosomal pH changes in living cells, tissues and zebrafish. Sensors & Actuators: B. Chemical, 2019, 290, 79-86. (通讯作者, IF>9.0, TOP, 1区, 他引大于12次)

17. Gangqiang Yuan, Haiyuan Ding, Hongyan Sun, Liyi Zhou^*, Qinlu Lin. A mitochondrion-targeting turn-on fluorescent probe detection of endogenous hydroxyl radicals in living cells and zebrafish. Sensors & Actuators: B. Chemical, 2019, 296, 126706. (通讯作者, IF>7.56, TOP, 1区)

18. Haiyuan Ding, Gangqiang Yuan, Longpeng Peng, Liyi Zhou^*, Qinlu Lin. A TP-FRET-based fluorescent sensor for ratiometric detection of formaldehyde in real food samples, living cells, tissues and zebrafish. J. Agric. Food Chem. 2020, 68(11), 3670-3677. (通讯作者, IF>5.0, TOP, 1区)

19. Gangqiang Yuan, Haiyuan Ding, Longpeng Peng, Liyi Zhou^*, Qinlu Lin. A novel fluorescent probe for ratiometric detection of formaldehyde in real food samples, living tissues and zebrafish. Food Chemistry, Volume 331, 30 November 2020Article 127221. (通讯作者, IF>6.0, TOP, 1区)

20. Liyi Zhou^*, FeijunLuo, Weijie Chi, Yiping Tang, Xiaogang Liu, Qinlu Lin. Activatable selenium-containing fluorescent apoptotic agent for biosensing and tracing cancer cell apoptosis. Sensors and Actuators B: Chemical, 2020, 311, 127915. (通讯作者, IF>7.0, TOP, 1区)

21. LibinTan, Haiyuan Ding, Supphachok Chanmungkalakul, Longpeng Peng, Gangqiang Yuan, Qiaomei Yang, Xiaogang Liu, Liyi Zhou^*, A smart TP-FRET-based ratiometric fluorescent sensor for bisulfite/formaldehyde detection and its imaging application, Sensors and Actuators B: Chemical, 2021, 345, 130331(通讯作者, IF>9.2, TOP, 1区)

22. Shu-Guo Sun, Haiyuan Ding, Gangqiang Yuan, Liyi Zhou^*. An efficient TP-FRET-based lysosome-targetable fluorescent probe for imaging peroxynitrite with two well-resolved emission channels in living cells, tissues and zebrafish. Analytica Chimica Acta, 2020, 1100, 200-207. (通讯作者, IF=6.0, TOP, 1区)

23. Haiyuan Ding, Longpeng Peng, Gangqiang Yuan, Liyi Zhou^*. Design, synthesis and bioimaging application of a novel two-photon xanthene fluorescence probe for ratiometric visualization of endogenous peroxynitrite in living cells and zebrafish. Dyes and Pigments, 2020, 176, 108232. (通讯作者, IF>4.6, TOP, 1区)

24. Liyi Zhou^*, Ding H, Zhao W, et al. A mitochondria targetable two-photon excited near-infrared fluorescent probe for imaging of H₂O₂ in live cells and tissues. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 206, 529-534. (第一和通讯作者, IF=3.232)

25. Ding H, Yuan G, Liyi Zhou^*. A new water-soluble two-photon fluorescent probe for detection of trace benzoyl peroxide in wheat flour and in living cell and tissue imaging. New J. Chem., 2019, 43, 3169-3173. (通讯作者, IF=3.288)

26. Gangqiang Yuan, Haiyuan Ding, Liyi Zhou^*. An effective FRET-based two-photon ratiometric fluorescent probe with double well-resolved emission bands for lysosomal pH changes in living cells and zebrafish. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 224, Article 117397. (通讯作者, IF=3.232)

27. Mei Zhao, Di Shi, Wandi Hu, Tao Ma, Lei He, Danqing Lu, Yunchu Hu, Liyi Zhou^*. A two-photon “turn-on” fluorescent probe for both exogenous and endogenous selenocysteine detection and imaging in living cells and zebrafish.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 260, Article 119983 (通讯作者, IF>4)